Complementation analysis of resistance to 5-fluorocytosine in Candida albicans.
نویسندگان
چکیده
A complementation test was devised to study allelism among the genetic determinants of resistance to 5-fluorocytosine in Candida albicans. Complementation was demonstrated in control hybrids produced by crossing a resistant strain that was deficient in cytosine deaminase activity with four other resistant strains deficient in UMP pyrophosphorylase activity. This complementation test was used to test allelism of the resistance determinants present in five clinical isolates. All were found to bear recessive alleles of the locus (FCY1) that determined 5-fluorocytosine resistance associated with low levels of UMP pyrophosphorylase activity.
منابع مشابه
In vitro studies of 5-fluorocytosine resistance in Candida albicans and Torulopsis glabrata.
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عنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 29 5 شماره
صفحات -
تاریخ انتشار 1986